Applying single-molecule optical and AFM imaging and pressure-spectroscopy procedures, we look for to unravel the mechanistic areas of the structure and dynamics of chromosomes. Our analysis passions include:

Our team reports bacterial mobile division and it is aiming to constitute a ‘base up biology’ in artificial cells that will autonomously divide. Our major desire lies in cell division, chromatin construction, and spatial control.

Across the same time, the team of Paul McEuen, who was then primarily based at the College of California, Berkeley, showed identical benefits on ropes of bundled nanotubes. According to the wrapping angle, nanotubes can come in metallic or semiconducting variants, a prediction that we and Charles Lieber’s team at Harvard University independently verified making use of scanning tunnelling spectroscopy experiments.

Deposition and atomic force microscopy of individual phthalocyanine polymers between nanofabricated electrodes

2012, discovery that nucleoid occlusion underlies the precision of bacterial mobile division; and to start with ever examine with the dynamics DNA supercoils and the invention of supercoil hopping

The coiled-coil of the human Rad50 DNA repair service protein includes specific segments of greater versatility

We use nanofabricated microfluidic constructions to sample spatial boundaries for microorganisms and biomimetic vesicles with reconstituted protein networks and this assess the fundamental role of spatial confinement at the molecular and mobile amount. Our initiatives involve the subsequent:

2011, to start with in vitro measurements of transportation throughout an individual biomimetic nuclear pore sophisticated; advancement of multiplexed magnetic tweezers for kilo-molecule experiments; and settled the mechanism of homology recognition in DNA homologous recombination

2003, shown the main biosensors built outside of a carbon nanotube; solved the construction and mechanism of DNA restore proteins; and discovery of a new technique for fabricating good-point out nanopores for DNA translocation

But carbon nanotubes have remained a analysis topic of significant interest to many. Without a doubt, the outlook on working with carbon nanotubes to build functional units, in regions for example radio-frequency electronics, electronic electronics and versatile electronics, stays brilliant.

‘The concept that There may be this kind of thing like a starting, a major bang, is already an interesting signpost to take into account that there was a creator. But extra usually, and on the basis of pure rationality, I also get there in a Christian interpretation of truth. An atheistic worldview is a naturalistic worldview: fundamentally, you'll find only atoms and normal forces that we could evaluate.

1999, initially measurement from the wavefunction of solitary molecular orbitals of carbon nanotubes; and discovery of kink heterojunctions of carbon nanotubes which gave decisive evidence for the new Luttinger description of interacting electrons in nanotubes

By way of example, we consider the nucleopore complicated, a gateway in between the mobile nucleus plus the cytoplasm. This is an extremely complex method and therefore tricky to ceesdekker.net review within a cell, so we use biomimetics. We reconstruct holes and afterwards insert specific components of the nucleopore advanced to review transportation by way of it at the single-molecule amount.’

Instance (2) of bending configurations in 3D simulations of DNA rods on nanopores. A percentage of the membrane is revealed in grey, the rim in the pore is highlighted in purple, and a 3D rendering in the movement of your DNA rod is displayed.